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Musical acculturation from infancy to adulthood was studied by testing the abilities of Western 6-month-olds and adults to notice mistunings in melodies based on native Western major, native Western minor, and non-native Javanese pelog scales. Results indicated that infants were similarly able to perceive native and non-native scales. Adults, however, were generally better perceivers of native than non-native scales. These findings suggest that infants are born with an equipotentiality for the perception of scales from a variety of cultures and that subsequent culturally specific experience substantially influences music perception.