Authors
Martin S Tallman, Janet W Andersen, Charles A Schiffer, Frederick R Appelbaum, James H Feusner, Angela Ogden, Lois Shepherd, Cheryl Willman, Clara D Bloomfield, Jacob M Rowe, Peter H Wiernik
Publication date
1997/10/9
Journal
New England Journal of Medicine
Volume
337
Issue
15
Pages
1021-1028
Publisher
Massachusetts Medical Society
Description
Background
All-trans-retinoic acid induces complete remission in acute promyelocytic leukemia. However, it is not clear whether induction therapy with all-trans-retinoic acid is superior to chemotherapy alone or whether maintenance treatment with all-trans-retinoic acid improves outcome.
Methods
Three hundred forty-six patients with previously untreated acute promyelocytic leukemia were randomly assigned to receive all-trans-retinoic acid or daunorubicin plus cytarabine as induction treatment. Patients who had a complete remission received consolidation therapy consisting of one cycle of treatment identical to the induction chemotherapy, then high-dose cytarabine plus daunorubicin. Patients still in complete remission after two cycles of consolidation therapy were then randomly assigned to maintenance treatment with all-trans-retinoic acid or to observation.
Results
Of the 174 patients treated with …
Total citations
Scholar articles
MS Tallman, JW Andersen, CA Schiffer, FR Appelbaum… - New England Journal of Medicine, 1997