Authors
Daniel J Sargent, Richard M Goldberg, Stacy D Jacobson, John S Macdonald, Roberto Labianca, Daniel G Haller, Lois E Shepherd, Jean François Seitz, Guido Francini
Publication date
2001/10/11
Journal
New England Journal of Medicine
Volume
345
Issue
15
Pages
1091-1097
Publisher
Massachusetts Medical Society
Description
Background
Adjuvant chemotherapy is standard treatment for patients with resected colon cancer who are at high risk for recurrence, but the efficacy and toxicity of such treatment in patients more than 70 years of age are controversial.
Methods
We performed a pooled analysis, based on the intention to treat, of individual patient data from seven phase 3 randomized trials (involving 3351 patients) in which the effects of postoperative fluorouracil plus leucovorin (five trials) or fluorouracil plus levamisole (two trials) were compared with the effects of surgery alone in patients with stage II or III colon cancer. The patients were grouped into four age categories of equal size, and analyses were repeated with 10-year age ranges (≤50, 51 to 60, 61 to 70, and >70 years), with the same conclusions. The toxic effects measured in all trials were nausea or vomiting, diarrhea, stomatitis, and leukopenia. Patients in the fluorouracil …
Total citations
Scholar articles
DJ Sargent, RM Goldberg, SD Jacobson… - New England Journal of Medicine, 2001