View article

Although detailed cell‐based descriptors of cross‐bridge cycling have been applied in finite element (FE) heart models to describe ventricular mechanics, these multiscale models have never been tested rigorously to determine if these descriptors, when scaled up to the organ‐level, are able to reproduce well‐established organ‐level physiological behaviors. To address this void, we here validate a left ventricular (LV) FE model that is driven by a cell‐based cross‐bridge cycling descriptor against key organ‐level heart physiology. The LV FE model was coupled to a closed‐loop lumped parameter circulatory model to simulate different ventricular loading conditions (preload and afterload) and contractilities. We show that our model is able to reproduce a linear end‐systolic pressure volume relationship, a curvilinear end‐diastolic pressure volume relationship and a linear relationship between myocardial oxygen …