Authors
John H Beigel, Kay M Tomashek, Lori E Dodd, Aneesh K Mehta, Barry S Zingman, Andre C Kalil, Elizabeth Hohmann, Helen Y Chu, Annie Luetkemeyer, Susan Kline, Diego Lopez de Castilla, Robert W Finberg, Kerry Dierberg, Victor Tapson, Lanny Hsieh, Thomas F Patterson, Roger Paredes, Daniel A Sweeney, William R Short, Giota Touloumi, David Chien Lye, Norio Ohmagari, Myoung-Don Oh, Guillermo M Ruiz-Palacios, Thomas Benfield, Gerd Fätkenheuer, Mark G Kortepeter, Robert L Atmar, C Buddy Creech, Jens Lundgren, Abdel G Babiker, Sarah Pett, James D Neaton, Timothy H Burgess, Tyler Bonnett, Michelle Green, Mat Makowski, Anu Osinusi, Seema Nayak, H Clifford Lane
Publication date
2020/11/5
Journal
New England Journal of Medicine
Volume
383
Issue
19
Pages
1813-1826
Publisher
Massachusetts Medical Society
Description
Background
Although several therapeutic agents have been evaluated for the treatment of coronavirus disease 2019 (Covid-19), no antiviral agents have yet been shown to be efficacious.
Methods
We conducted a double-blind, randomized, placebo-controlled trial of intravenous remdesivir in adults who were hospitalized with Covid-19 and had evidence of lower respiratory tract infection. Patients were randomly assigned to receive either remdesivir (200 mg loading dose on day 1, followed by 100 mg daily for up to 9 additional days) or placebo for up to 10 days. The primary outcome was the time to recovery, defined by either discharge from the hospital or hospitalization for infection-control purposes only.
Results
A total of 1062 patients underwent randomization (with 541 assigned to remdesivir and 521 to placebo). Those who received remdesivir had a median recovery time of 10 days (95% confidence …
Scholar articles
JH Beigel, KM Tomashek, LE Dodd, AK Mehta… - New England Journal of Medicine, 2020
JH Beigel, KM Tomashek, LE Dodd, AK Mehta… - Remdesivir for the treatment of Covid-19—final report …, 2020
JH Beigel, KM Tomashek, LE Dodd, AK Mehta… - Remdesivir for the treatment of COVID-19—final report …
JH Beigel, KM Tomashek, LE Dodd, AK Mehta… - N Engl J Med. https://doi. org/10.1056 …
DCT Team - New England Journal of Medicine, 2020
Beigel, JH, KM Tomashek, LE Dodd, AK Mehta, BS … - New England Journal of Medicine, 2020