Authors
Paul E Verweij, Roger JM Brüggemann, Elie Azoulay, Matteo Bassetti, Stijn Blot, Jochem B Buil, Thierry Calandra, Tom Chiller, Cornelius J Clancy, Oliver A Cornely, Pieter Depuydt, Philipp Koehler, Katrien Lagrou, Dylan de Lange, Cornelia Lass-Flörl, Russell E Lewis, Olivier Lortholary, Peter-Wei Lun Liu, Johan Maertens, M Hong Nguyen, Thomas F Patterson, Bart JA Rijnders, Alejandro Rodriguez, Thomas R Rogers, Jeroen A Schouten, Joost Wauters, Frank L van de Veerdonk, Ignacio Martin-Loeches
Publication date
2021/8
Journal
Intensive care medicine
Volume
47
Issue
8
Pages
819-834
Publisher
Springer Berlin Heidelberg
Description
Purpose
Invasive pulmonary aspergillosis (IPA) is increasingly reported in patients with severe coronavirus disease 2019 (COVID-19) admitted to the intensive care unit (ICU). Diagnosis and management of COVID-19 associated pulmonary aspergillosis (CAPA) are challenging and our aim was to develop practical guidance.
Methods
A group of 28 international experts reviewed current insights in the epidemiology, diagnosis and management of CAPA and developed recommendations using GRADE methodology.
Results
The prevalence of CAPA varied between 0 and 33%, which may be partly due to variable case definitions, but likely represents true variation. Bronchoscopy and bronchoalveolar lavage (BAL) remain the cornerstone of CAPA diagnosis, allowing for diagnosis of invasive Aspergillus tracheobronchitis and collection of the best validated specimen for Aspergillus diagnostics. Most patients diagnosed …
Total citations
Scholar articles
PE Verweij, RJM Brüggemann, E Azoulay, M Bassetti… - Intensive care medicine, 2021