Authors
Ana I Romero, Martin Lagging, Johan Westin, Amar P Dhillon, Lynn B Dustin, Jean-Michel Pawlotsky, Avidan U Neumann, Carlo Ferrari, Gabriele Missale, Bart L Haagmans, Solko W Schalm, Stefan Zeuzem, Francesco Negro, Elke Verheij-Hart, DITTO-HCV Study Group
Publication date
2006/10/1
Journal
The Journal of infectious diseases
Volume
194
Issue
7
Pages
895-903
Publisher
The University of Chicago Press
Description
BackgroundWe investigated associations between interferon (IFN)–γ–inducible protein (IP)–10 and liver histological results, viral kinetic response, and treatment outcome in patients infected with hepatitis C virus (HCV) genotypes 1–4
MethodsPlasma IP-10 was monitored before, during, and after treatment with pegylated IFN-α2a and ribavirin in 265 HCV-infected patients
ResultsIn univariate analyses, a low baseline IP-10 level was significantly associated with low baseline viral load, rapid viral response (RVR), a sustained viral response (SVR), body mass index <25 kg/m2, and less-pronounced fibrosis, inflammation, and steatosis (for HCV genotypes other than 3). When the results of the univariate analyses were included in multivariate analyses, a low plasma IP-10 level, low baseline viral load, and genotype 2 or 3 infection were independent predictors of an RVR and SVR. IP-10 …
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Scholar articles
AI Romero, M Lagging, J Westin, AP Dhillon, LB Dustin… - The Journal of infectious diseases, 2006
AI Romero, M Lagging, J Westin, AP Dhillon, LB Dustin… - Journal of Infectious Diseases, 2006