Authors
Ratna B Ray, L Martin Lagging, Keith Meyer, Robert Steele, Ranjit Ray
Publication date
1995/8/1
Journal
Virus research
Volume
37
Issue
3
Pages
209-220
Publisher
Elsevier
Description
The genomic region encoding the hepatitis C virus (HCV) core protein was cloned into a mammalian expression vector to study its role on the transcriptional regulation of cellular proto-oncogene and viral promoters. Using a transient transfection assay in human hepato-cellular carcinoma (HepG2) cells, we demonstrate that the HCV core protein activates the human c-myc, Rous sarcoma virus long terminal repeat (LTR), and simian virus 40 (SV40) early promoters; and suppresses the c-fos promoter and human immunodeficiency virus type 1 (HIV-1) LTR activity. The transcriptional regulation of cellular proto-oncogenes by the HCV core protein suggests possible involvement of the core protein in the deregulation of normal hepatocyte growth and hepatocarcinogenesis.
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Scholar articles
RB Ray, LM Lagging, K Meyer, R Steele, R Ray - Virus research, 1995