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WHO recommends that SARS-CoV-2 vaccine antigens should target circulating variants. 1 The emergent Omicron BA. 2.86 variant displays 61 amino acid mutations relative to the ancestral B. 1 lineage used in first-generation vaccines. 2 Many of these mutations are predicted to affect neutralisation; 3 hence, there is an urgent need for data on existing cross-protective immunity in the general population, as well as vaccine effectiveness of available XBB. 1.5-based vaccines. We screened sera derived from a UK single-centre cohort of healthy vaccinated individuals from the DOVE study (appendix pp 1–2); 4 participants were a median age of 52 years (range 29–66) and, of the

36 participants, 20 (56%) were female and 16 (44%) were male. Participants received four doses of vaccine: two doses of ChAdOx1 (AstraZeneca), or BNT162b2 (Pfizer–BioNTech), or mRNA-1273 (Moderna) in early 2021, followed by a …