Authors
Marie-Laure Welter, Michael Schüpbach, Virginie Czernecki, Carine Karachi, Sara Fernandez-Vidal, Jean-Louis Golmard, Giulia Serra, Soledad Navarro, Arlette Welaratne, Andréas Hartmann, Valérie Mesnage, Fanny Pineau, Philippe Cornu, Bernard Pidoux, Yulia Worbe, Panayiotis Zikos, David Grabli, Damien Galanaud, Anne-Marie Bonnet, Hayat Belaid, Didier Dormont, Marie Vidailhet, Luc Mallet, Jean-Luc Houeto, Eric Bardinet, Jerome Yelnik, Yves Agid
Publication date
2014/4/15
Journal
Neurology
Volume
82
Issue
15
Pages
1352-1361
Publisher
Lippincott Williams & Wilkins
Description
Objective
To further determine the causes of variable outcome from deep brain stimulation of the subthalamic nucleus (DBS-STN) in patients with Parkinson disease (PD).
Methods
Data were obtained from our cohort of 309 patients with PD who underwent DBS-STN between 1996 and 2009. We examined the relationship between the 1-year motor, cognitive, and psychiatric outcomes and (1) preoperative PD clinical features, (2) MRI measures, (3) surgical procedure, and (4) locations of therapeutic contacts.
Results
Pre- and postoperative results were obtained in 262 patients with PD. The best motor outcome was obtained when stimulating contacts were located within the STN as compared with the zona incerta (64% vs 49% improvement). Eighteen percent of the patients presented a postoperative cognitive decline, which was found to be principally related to the surgical procedure. Other factors predictive of poor …
Scholar articles
ML Welter, M Schüpbach, V Czernecki, C Karachi… - Neurology, 2014