Authors
Florence Le Jeune, Marc Vérin, Karim N'Diaye, Dominique Drapier, Emmanuelle Leray, Sophie Tezenas Du Montcel, Nicolas Baup, Antoine Pelissolo, Mircea Polosan, Luc Mallet, Jérome Yelnik, Bertrand Devaux, Denys Fontaine, Isabelle Chereau, Aurélie Bourguignon, Julie Peron, Paul Sauleau, Sylvie Raoul, Etienne Garin, Marie-Odile Krebs, Nematollah Jaafari, Bruno Millet, French Stimulation dans le trouble obsessionnel compulsif (STOC) study group
Publication date
2010/12/1
Journal
Biological psychiatry
Volume
68
Issue
11
Pages
1016-1022
Publisher
Elsevier
Description
BACKGROUND
High-frequency bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) is a promising treatment in refractory obsessive-compulsive disorder (OCD).
METHOD
Using the crossover, randomized, and double-blind procedure adopted by the STOC study, 10 patients treated with high-frequency bilateral STN DBS underwent am 18-fluorodeoxyglucose positron emission tomography (PET) investigation to highlight the neural substratum of this therapeutic approach.
RESULTS
The median Yale–Brown Obsessive Compulsive Scale (Y-BOCS) scores for all 10 patients were 31 (minimum = 18, maximum = 36) with “Off-Stimulation” status and 19 (minimum = 0, maximum = 30) with “On-Stimulation” status (p = .05). The OCD patients in Off-Stimulation status showed a hypermetabolism in the right frontal middle and superior gyri, right parietal lobe, postcentral gyrus, and bilateral putamen compared …
Total citations
Scholar articles
F Le Jeune, M Vérin, K N'Diaye, D Drapier, E Leray… - Biological psychiatry, 2010