Authors
Marie-Laure Welter, Luc Mallet, Jean-Luc Houeto, Carine Karachi, Virginie Czernecki, Philippe Cornu, Soledad Navarro, Bernard Pidoux, Didier Dormont, Eric Bardinet, Jérôme Yelnik, Philippe Damier, Yves Agid
Publication date
2008/7/14
Journal
Archives of Neurology
Volume
65
Issue
7
Pages
952-957
Publisher
American Medical Association
Description
Background
Tourette syndrome (TS) is thought to result from dysfunction of the associative-limbic territories of the basal ganglia, and patients with severe symptoms of TS respond poorly to medication. High-frequency stimulation has recently been applied to patients with TS in open studies using the centromedian-parafascicular complex (CM-Pf) of the thalamus, the internal globus pallidus (GPi), or the anterior limb of the internal capsule as the principal target.
Objective
To report the effect of high-frequency stimulation of the CM-Pf and/or the GPi, 2 associative-limbic relays of the basal ganglia, in patients with TS.
Design
Controlled, double-blind, randomized crossover study.
Setting
Medical research.
Patients
Three patients with severe and medically refractory TS.
Intervention
Bilateral placement of stimulating electrodes in the CM-Pf (associative-limbic part of the thalamus) and the GPi (ventromedial part).
Main Outcome …
Total citations
Scholar articles
ML Welter, L Mallet, JL Houeto, C Karachi, V Czernecki… - Archives of neurology, 2008