Authors
Luc Mallet, Mircea Polosan, Nematollah Jaafari, Nicolas Baup, Marie-Laure Welter, Denys Fontaine, Sophie Tezenas du Montcel, Jérôme Yelnik, Isabelle Chéreau, Christophe Arbus, Sylvie Raoul, Bruno Aouizerate, Philippe Damier, Stephan Chabardès, Virginie Czernecki, Claire Ardouin, Marie-Odile Krebs, Eric Bardinet, Patrick Chaynes, Pierre Burbaud, Philippe Cornu, Philippe Derost, Thierry Bougerol, Benoit Bataille, Vianney Mattei, Didier Dormont, Bertrand Devaux, Marc Vérin, Jean-Luc Houeto, Pierre Pollak, Alim-Louis Benabid, Yves Agid, Paul Krack, Bruno Millet, Antoine Pelissolo
Publication date
2008/11/13
Journal
New England Journal of Medicine
Volume
359
Issue
20
Pages
2121-2134
Publisher
Massachusetts Medical Society
Description
Background
Severe, refractory obsessive–compulsive disorder (OCD) is a disabling condition. Stimulation of the subthalamic nucleus, a procedure that is already validated for the treatment of movement disorders, has been proposed as a therapeutic option.
Methods
In this 10-month, crossover, double-blind, multicenter study assessing the efficacy and safety of stimulation of the subthalamic nucleus, we randomly assigned eight patients with highly refractory OCD to undergo active stimulation of the subthalamic nucleus followed by sham stimulation and eight to undergo sham stimulation followed by active stimulation. The primary outcome measure was the severity of OCD, as assessed by the Yale–Brown Obsessive Compulsive Scale (Y-BOCS), at the end of two 3-month periods. General psychopathologic findings, functioning, and tolerance were assessed with the use of standardized psychiatric scales, the …
Total citations
Scholar articles
L Mallet, M Polosan, N Jaafari, N Baup, ML Welter… - New England Journal of Medicine, 2008
L Mallet, M Polosan, N Jaafari, N Baup, ML Welter… - New England Journal of Medicine, 2009