Authors
Roger G Owen, Steven P Treon, Ayad Al-Katib, Rafael Fonseca, Philip R Greipp, Mary L McMaster, Enrica Morra, Gerassimos A Pangalis, Jesus F San Miguel, Andrew R Branagan, Meletios A Dimopoulos
Publication date
2003/4/1
Source
Seminars in oncology
Volume
30
Issue
2
Pages
110-115
Publisher
WB Saunders
Description
This presentation represents consensus recommendations for the clinicopathological definition of Waldenstrom's macroglobulinemia (WM), which were prepared in conjunction with the Second International Workshop held in Athens, Greece during September 2002. WM is an uncommon lymphoproliferative disorder characterized primarily by bone marrow infiltration and IgM monoclonal gammopathy. It should be considered a distinct clinicopathological entity rather than a clinical syndrome secondary to IgM secretion. The underlying pathological diagnosis in WM is lymphoplasmacytic lymphoma as defined by the World Health Organization (WHO) and Revised European-American Lymphoma (REAL) classification criteria. The concentration of monoclonal IgM can vary widely in WM and it is not possible to define a concentration that reliably distinguishes WM from monoclonal gammopathy of undetermined …
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RG Owen, SP Treon, A Al-Katib, R Fonseca, PR Greipp… - Seminars in oncology, 2003