Authors
Celina Wettstein, Catrina Mugglin, Matthias Egger, Nello Blaser, Luisa S Vizcaya, Janne Estill, Nicole Bender, Mary-Ann Davies, Gilles Wandeler, Olivia Keiser, IeDEA Southern Africa Collaboration
Publication date
2012/11/28
Source
Aids
Volume
26
Issue
18
Pages
2361-2373
Publisher
LWW
Description
Objectives:
To determine magnitude and reasons of loss to program and poor antiretroviral prophylaxis coverage in prevention of mother-to-child transmission (PMTCT) programs in sub-Saharan Africa.
Design:
Systematic review and meta-analysis.
Methods:
We searched PubMed and Embase databases for PMTCT studies in sub-Saharan Africa published between January 2002 and March 2012. Outcomes were the percentage of pregnant women tested for HIV, initiating antiretroviral prophylaxis, having a CD4 cell count measured, and initiating antiretroviral combination therapy (cART) if eligible. In children outcomes were early infant diagnosis for HIV, and cART initiation. We combined data using random-effects meta-analysis and identified predictors of uptake of interventions.
Results:
Forty-four studies from 15 countries including 75 172 HIV-infected pregnant women were analyzed. HIV-testing uptake at antenatal …
Scholar articles
C Wettstein, C Mugglin, M Egger, N Blaser, LS Vizcaya… - Aids, 2012