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The transition towards Circular Economy is needed, all the more in industries with a harmful environmental impact such as the textile and fashion ones. This transformation, however, presents several challenges. While these challenges have been widely investigated in literature, solutions to overcome them have received much less attention to date. Practices and strategies proposed by the literature are still largely fragmented and not interpreted through an overarching theory, which prevents the understanding of how circular supply chains should be managed and coordinated. Therefore, this paper proposes a circular supply chain orchestration approach to understand responses to Circular Economy adoption barriers in the textile and fashion supply chains. A multiple case study has been carried out in the Prato (Italy) regenerated wool district, which has been practicing Circular Economy for more than a century …