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Circular Economy promises to achieve sustainability by decoupling economic growth from resource extraction and environmental losses. However, it requires a systemic change in the design of products, business models and supply chains. In this study the evolution of the supply chain structure and relationships is addressed in the specific context of industrial districts – i.e., agglomerations of small and medium-sized firms territorially concentrated and specialised in one or more phases of a production process – undergoing a transition to Circular Economy. Through the study of the textile industrial district in Prato (Italy), this study addresses two topics that have been limitedly investigated in the literature. First, the potential role of Circular Economy in revitalising an industrial district in a decline phase. Second, how supply chain structure and relationships should evolve in an industrial district transitioning to Circular …