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Artificial neural networks (ANN) are a type of machine learning model that has been applied to various genomic problems, with the ability to learn non-linear relationships and model high-dimensional data. ANNs also have the potential in genomic prediction by capturing the intricate relationship between genetic variants and phenotypes. However, there is currently a limited effort to investigate the performance and feasibility of ANNs for pig genomic predictions. In this study, we evaluated the predictive performance of TensorFlow’s ANN models with one-layer, two-layer, and three-layer structures (with zero, one, and two hidden layers, respectively), in comparison with five linear methods, including GBLUP, LDAK, BayesR, SLEMM and scikit-learn’s ridge regression using data of six quantitative traits including off-test body weight (WT), off-test back fat thickness (BF), off-test loin muscle depth (MS), number of …