Authors
Giuseppe Paolisso, Saverio Sgambato, Dario Giugliano, Gennaro Pizza, Paola Tesauw, Michele Varricchio, Felice D’Onofrio, Tarja Porkka-Heiskanen, Maija-Liisa Laakso, Gunnar Johansson, Dag Stenberg, Mikael Peder, F Mounier, MT Bluet-Pajot, D Durand, C Kordon, R Rasolonjanahary, J Epelbaum, J Ludvigsson, EA Werder, M Zachmann, W Wichmann, A Valavanis, Lars Gelander, Göran Lindstedt, Gunnar Selstam, Leif Wide, Kerstin Albertsson-Wikland, Sarah Jane Schwarzenberg, Harvey L Sharp, Esther F Freier, T Barreca, R Franceschini, V Messina, B Bertoli, S Caputo, MA Marini, SA Santini, G Ghirlanda, AV Greco, Joseph C Dunbar, Susan Schultz, Felicia Houser, Jesse Walker, A Berghout, WM Wiersinga, WH Brummelkamp, Raphaël Rappaport, Raja Brauner, D Gordon, GH Beastall, JA Thomson, A Cataldi, M Salvemini, E Rolandi, Steven Seelig
Publication date
1989
Journal
Hormone Research in Paediatrics
Volume
31
Issue
5-6
Pages
193-203
Publisher
Karger Publishers
Description
It has been suggested that signs of neuropathy appear earlier than other microvascular complications in diabetes mellitus. To evaluate the influence of intensified conventional insulin therapy (ICIT) in the prevention of diabetic microangiopathy, the preclini-cal signs of autonomic neuropathy, resting heart rate (RHR), hyperventilatory arrhythmia, standing/lying heart rate ratio (S/L), ortho-static decrease in blood pressure and increase in blood pressure during sustained handgrip, were investigated in children with type I diabetes (mean age: 12.2±2.3 years, mean duration of diabetes: 3.9±0.8 years) who had been treated since the onset of disease with:(1) twice a day monocomponent insulin (n= 15);(2) twice a day semisynthetic human insulin (n= 10), or (3) ICIT by means of NovoPen (n= 9). Their results were compared with those of an age-matched healthy control group (n= 20). Comparing diabetic children treated …
Scholar articles
G Paolisso, S Sgambato, D Giugliano, G Pizza… - Hormone Research in Paediatrics, 1989