Authors
Karin M Gilljam, Patrik Stenlund, Simon Standoft, Sisse Bindslev Andersen, Kari Kaaber, Henrik Lund, Karl RK Bryn
Publication date
2023/9/1
Journal
Journal of Burn Care & Research
Volume
44
Issue
5
Pages
1140-1149
Publisher
Oxford University Press
Description
Partial-thickness thermal burn wounds are characterized by a prolonged inflammatory response, oxidative stress, tissue damage, and secondary necrosis. An optimal dressing for burn wounds would reduce inflammation and oxidative stress while providing a moist, absorbent, and protective cover. We have developed an extract from unfertilized salmon roe containing components with potential anti-inflammatory and antioxidative properties, called HTX. HTX has been combined with alginate from brown algae and nanocellulose from tunicates, and 3D printed into a solid hydrogel wound dressing called Collex. Here, Collex was tested on partial thickness burn wounds in Göttingen minipigs compared to Jelonet, and a variant of Collex without HTX. We found that dermal treatment of burn wounds with Collex resulted in accelerated healing at a majority of measured points over 23 days, compared to treatment with …
Total citations
2023202412