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It is well-known that quantum programs are not only complicated to design but also challenging to verify because the quantum states can have exponential size and require sophisticated mathematics to encode and manipulate. To tackle the state-space explosion problem for quantum reasoning, we propose a Hoare-style inference framework that supports local reasoning for quantum programs. By providing a quantum interpretation of the separating conjunction, we are able to infuse separation logic into our framework and apply local reasoning using a quantum frame rule that is similar to the classical frame rule. For evaluation, we apply our framework to verify various quantum programs including Deutsch–Jozsa’s algorithm and Grover's algorithm.