Authors
Mariangela Rondanelli, Federica Fossari, Viviana Vecchio, Clara Gasparri, Gabriella Peroni, Daniele Spadaccini, Antonella Riva, Giovanna Petrangolini, Giancarlo Iannello, Mara Nichetti, Vittoria Infantino, Simone Perna
Publication date
2020/11
Source
Phytotherapy Research
Volume
34
Issue
11
Pages
2843-2856
Publisher
John Wiley & Sons, Ltd.
Description
Ginger has a pain‐reducing effect and it can modulate pain through various mechanisms: inhibition of prostaglandins via the COX and LOX‐pathways, antioxidant activity, inibition of the transcription factor nf–kB, or acting as agonist of vanilloid nociceptor. This narrative review summarizes the last 10‐year of randomized controlled trials (RCTs), in which ginger was traditionally used as a pain reliever for dysmenorrhea, delayed onset muscle soreness (DOMS), osteoarthritis (AO), chronic low back pain (CLBP), and migraine. Regarding dysmenorrhea, six eligible studies suggest a promising effect of oral ginger. As concerned with DOMS, the four eligible RCTs suggested a reduction of inflammation after oral and topical ginger administration. Regarding knee AO, nine RCTs agree in stating that oral and topical use of ginger seems to be effective against pain, while other did not find significant differences. One RCT …
Total citations
20172018201920202021202220232024114293313
Scholar articles
M Rondanelli, F Fossari, V Vecchio, C Gasparri… - Phytotherapy Research, 2020