Authors
Pedro Kurtz, Leonardo SL Bastos, Leila F Dantas, Fernando G Zampieri, Marcio Soares, Silvio Hamacher, Jorge IF Salluh, Fernando A Bozza
Publication date
2021/5
Journal
Intensive care medicine
Volume
47
Pages
538-548
Publisher
Springer Berlin Heidelberg
Description
Purpose
Clinical characteristics and management of COVID-19 patients have evolved during the pandemic, potentially changing their outcomes. We analyzed the associations of changes in mortality rates with clinical profiles and respiratory support strategies in COVID-19 critically ill patients.
Methods
A multicenter cohort of RT-PCR-confirmed COVID-19 patients admitted at 126 Brazilian intensive care units between February 27th and October 28th, 2020. Assessing temporal changes in deaths, we identified distinct time periods. We evaluated the association of characteristics and respiratory support strategies with 60-day in-hospital mortality using random-effects multivariable Cox regression with inverse probability weighting.
Results
Among the 13,301 confirmed-COVID-19 patients, 60-day in-hospital mortality was 13 …
Total citations
Scholar articles
P Kurtz, LSL Bastos, LF Dantas, FG Zampieri, M Soares… - Intensive care medicine, 2021