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Studies investigating the crossover of job stress and strain between partners have shown that job demands are transmitted from job incumbents to their partners, affecting their psychological and physical health. Based on the crossover literature and on models of job stress and the work-family interface, this study develops a comprehensive framework to integrate the literature conceptually, delineating the mechanisms that underlie the crossover process. Key constructs include job stress, life events, strain, personal attributes and interpersonal factors. The literature pertaining to each construct in the model is reviewed and summarized. Gaps in the literature are identified, recommendations for future research are proposed, and the implications for organizational theory and practice are discussed.