Authors
A Hernandez-Sanchez, A Villaverde-Ramiro, J Martínez Elicegui, T Gonzalez, A Benner, E Sträng, G Castellani, CA Heckman, J Versluis, M Abaigar, M Sobas, R Azibeiro, L Tur, PJ Valk, KH Metzeler, R Ayala, D Dall’Olio, J Tettero, J Martínez-López, H Dombret, M Pratcorona, F Damm, KI Mills, J Mayer, C Thiede, MT Voso, GF Sanz, F Calado, K Döhner, VI Gaidzik, M Heuser, T Haferlach, AT Turki, D Reinhardt, R Villoria Medina, M van Speybroeck, R Schulze-Rath, M Barbus, JE Butler, JM Hernández Rivas, BJ Huntly, GJ Ossenkoppele, H Döhner, L Bullinger
Publication date
2022/6/1
Journal
HemaSphere
Volume
6
Pages
31-32
Publisher
LWW
Description
Background: Acute myeloid leukemia (AML) is a heterogeneous disease in terms of clinical features, outcomes and genetics. While mutations of NPM1 are usually considered as a favorable prognostic marker, the vast majority of the patients carry several co-mutations that might influence the prognosis. Therefore, a better understanding of the NPM1 mut AML mutational landscape is warranted. The large cohort of AML patients collected within the European HARMONY Alliance provides an excellent basis for this purpose.
Aims: To identify clinically significant co-mutational patterns in NPM1 mut AML in order to establish a revised risk stratification model.
Methods: From the HARMONY Alliance AML database, a total of 1001 NPM1 mut intensively treated patients were selected. Clinically significant co-mutations were evaluated using graphical patterns created with the Gephi tool and confirmed by detailed survival …
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Scholar articles
A Hernández-Sánchez, Á Villaverde-Ramiro… - HemaSphere, 2022