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Human studies of dopamine D2/D3 receptors using ¹⁸F‐fallypride‐PET in normal volunteers were performed to evaluate brain distribution in striatal and extrastriatal regions, evaluate metabolites in blood plasma, establish PET imaging protocol for this new radiotracer, evaluate graphical methods of analysis to quantitate D2/D3 receptors, and assess the ability of ¹⁸F‐fallypride to measure changes in D2/D3 receptors with aging as a model. Subjects (6; 21–63 years) had a PET scan on a Siemens HR+ scanner with ¹⁸F‐fallypride and a T1‐weighted MRI scan on a 1.5T GE scanner for purposes of anatomical coregistration with PET. A 3‐h PET scan with ¹⁸F‐fallypride (0.07 mCi/Kg) was carried out on each subject and repeated in 4–6 weeks. Arterial or arterialized venous blood was obtained in all subjects in order to evaluate blood activity levels and analyze metabolites in the plasma. Brain regions‐of‐interest …