Authors
M Reza Mirbolooki, Cristian C Constantinescu, Min-Liang Pan, Jogeshwar Mukherjee
Publication date
2011/12
Journal
EJNMMI research
Volume
1
Pages
1-11
Publisher
Springer Berlin Heidelberg
Description
Background
Brown adipose tissue [BAT] metabolism in vivo is vital for the development of novel strategies in combating obesity and diabetes. Currently, BAT is activated at low temperatures and measured using 2-deoxy-2-18F-fluoro-D-glucose [18F-FDG] positron-emission tomography [PET]. We report the use of β3-adrenergic receptor-mediated activation of BAT at ambient temperatures using (R, R)-5-[2-[2,3-(3-chlorphenyl)-2-hydroxyethyl-amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate, disodium salt [CL316,243] (a selective β3-adrenoceptor agonist) and measured by 18F-FDG PET/computed tomography [CT].
Methods
Control and CL316,243-treated (2 mg/kg) male Sprague-Dawley rats were administered with 18F-FDG for PET/CT studies and were compared to animals at cold temperatures. Receptor-blocking experiments were carried out using …
Total citations
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Scholar articles
MR Mirbolooki, CC Constantinescu, ML Pan… - EJNMMI research, 2011