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Recent research has demonstrated the multidimensional and multi-scalar nature of climate change, evidencing the need to develop integrated tools for the analysis of impacts and adaptation. This research presents a hydro-economic model of the Middle-Guadiana basin, Spain, to assess potential effects of climate change on irrigated agriculture and options for adaptation. It combines a farm-based economic optimisation model with the hydrologic model WEAP, and represents the socio-economic, agronomic and hydrologic systems in a spatially-explicit manner covering all dimensions and scales relevant to climate change. Simulated scenarios include a severe A2 climate change scenario up to 2070, two policy-based adaptation scenarios, and autonomous adaptation. Results show that climate change may impact severely irrigation systems reducing water availability and crop yields, and increasing irrigation …