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Nowadays, large-scale optimization problems are ubiquitous in many research fields. To deal with such problems efficiently, this paper proposes a distributed differential evolution with adaptive mergence and split (DDE-AMS) on subpopulations. The novel mergence and split operators are designed to make full use of limited population resource, which is important for large-scale optimization. They are adaptively performed based on the performance of the subpopulations. During the evolution, once a subpopulation finds a promising region, the current worst performing subpopulation will merge into it. If the merged subpopulation could not continuously provide competitive solutions, it will be split in half. In this way, the number of subpopulations is adaptively adjusted and better performing subpopulations obtain more individuals. Thus, population resource can be adaptively arranged for subpopulations during the …