Authors
Nele Moreels, Annelies Boven, Oswaldo Gressani, Fredrik L Andersson, Erika Vlieghe, Steven Callens, Lars Engstrand, Johanna Simin, Nele Brusselaers
Publication date
2024/3
Journal
Journal of Antimicrobial Chemotherapy
Volume
79
Issue
3
Pages
608-616
Publisher
Oxford University Press
Description
Background
Antibiotics and proton pump inhibitors (PPI) are recognized risk factors for acquisition and recurrence of Clostridioides difficile infection (CDI), yet combined effects remain unclear.
Objectives
To assess the short- and long-term effects of antibiotics and PPIs on CDI risk and recurrence.
Methods
Population-based study including all 43 152 patients diagnosed with CDI in Sweden (2006–2019), and 355 172 matched population controls without CDI. The impact of antibiotics and PPIs on CDI risk and recurrence was explored for recent (0–30 days) and preceding (31–180 days) use prior to their first CDI diagnosis, using multivariable conditional logistic regression presented as odds ratios (ORs) and 95% confidence interval, adjusted for demographics, comorbidities and other drugs.
Results
Compared to controls, the combined …
Total citations
20242
Scholar articles
N Moreels, A Boven, O Gressani, FL Andersson… - Journal of Antimicrobial Chemotherapy, 2024