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A spatial resolution needs to be determined prior to using models to simulate crop yields at a regional scale, but a dilemma exists in compromising between different demands. A fine spatial resolution demands extensive computation load for input data assembly, model runs, and output analysis. A coarse spatial resolution could result in loss of spatial detail in variability. This paper studied the impact of spatial resolution, data aggregation and spatial heterogeneity of weather data on simulations of crop yields, thus providing guidelines for choosing a proper spatial resolution for simulations of crop yields at regional scale. Using a process-based crop model SIMPLACE and daily weather data at 1 km resolution we simulated a continuous rainfed winter wheat cropping system at the national scale of Germany. Then we aggregated the weather data to four resolutions from 10 to 100 km, repeated the simulation …