Authors
Caryn G Morse, Joachim G Voss, Goran Rakocevic, Mary McLaughlin, Carol L Vinton, Charles Huber, Xiaojun Hu, Jun Yang, Da Wei Huang, Carolea Logun, Robert L Danner, Zoila G Rangel, Peter J Munson, Jan M Orenstein, Elisabeth J Rushing, Richard A Lempicki, Marinos C Dalakas, Joseph A Kovacs
Publication date
2012/6/15
Journal
Journal of Infectious Diseases
Volume
205
Issue
12
Pages
1778-1787
Publisher
Oxford University Press
Description
Background. Although human immunodeficiency virus (HIV) infection and antiretroviral therapy (ART) affect mitochondrial DNA (mtDNA) content and function, comprehensive evaluations of their effects on mitochondria in muscle, adipose tissue, and blood cells are limited.
Methods. Mitochondrial DNA quantification, mitochondrial genome sequencing, and gene expression analysis were performed on muscle, adipose tissue, and peripheral blood mononuclear cell (PBMC) samples from untreated HIV-positive patients, HIV-positive patients receiving nucleoside reverse transcriptase inhibitor (NRTI)–based ART, and HIV-negative controls.
Results. The adipose tissue mtDNA/nuclear DNA (nDNA) ratio was increased in untreated HIV-infected patients (ratio, 353) and decreased in those receiving ART (ratio, 162) compared with controls (ratio …
Scholar articles
CG Morse, JG Voss, G Rakocevic, M McLaughlin… - Journal of Infectious Diseases, 2012