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This study focused on preparation of curcumin (CUR) loaded poly (lactic acid) (PLA) nanofibers by electrospinning technique. The hydrophilicity of nanofibers was modified by the addition of poly (ethylene glycol) (PEG) with molecular weight of 1500 in different weight (0, 5, 10, 15, and 20 wt% related to the PLA content) and also by the addition of PEG with different molecular weights (6000, 3350, 1500, 600, 400) in the same content of 10 wt% related to the PLA content. The electrospun PLA/CUR/PEG nanofibers are characterized by scanning electron microscopy, differential scanning calorimetry, Fourier-transform infrared spectroscopy, contact angle measurements and weight loss investigation in the phosphate buffered saline. Vertical diffusion cell was used to perform in vitro drug release from the prepared nanofiber mats through recording curcuminoids content by high performance liquid chromatography. The …