Authors
CFL Amar, CL East, J Gray, M Iturriza-Gomara, EA Maclure, James McLauchlin
Publication date
2007/5
Journal
European Journal of Clinical Microbiology & Infectious Diseases
Volume
26
Pages
311-323
Publisher
Springer-Verlag
Description
The English case-control Infectious Intestinal Disease Study (1993–1996) failed to detect an enteric pathogen or toxin in 49% of cases of gastroenteritis. In the present study, polymerase chain reaction (PCR) assays were applied to DNA and cDNA generated from 4,627 faecal samples from cases and controls archived during the original study for the detection of norovirus, rotavirus, sapovirus, Campylobacter spp., Salmonella spp., enteroaggregative Escherichia coli, Cryptosporidium spp., and Giardia spp. The percentage of archived samples from cases and from controls in which at least one agent (or toxin) was detected increased from 53% in the original study to 75% and from 19 to 42%, respectively, after the application of PCR assays. Among cases, the following percentages of enteric pathogens were detected: norovirus 36%, rotavirus A 31%, sapovirus 4%, Salmonella spp. 6%, Campylobacter jejuni …
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