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Biological cells are characterized by highly complex phenomena and processes that are, to a great extent, interdependent. To gain detailed insights, devices designed to study cellular phenomena need to enable tracking and manipulation of multiple cell parameters in parallel; they have to provide high signal quality and high-spatiotemporal resolution. To this end, we have developed a CMOS-based microelectrode array system for in vitro applications that integrates six measurement and stimulation functions, the largest number to date. Moreover, the system features the largest active electrode array area to date (4.48 × 2.43 mm ² ) to accommodate 59760 electrodes, while its power consumption, noise characteristics, and spatial resolution (13.5-μm electrode pitch) are comparable to the best state-of-the-art devices. The system includes: 2048 action potential (AP, bandwidth: 300 Hz-10 kHz) recording units, 32 …