Authors
Writing group leaders Pathak Gita A. 6 Andrews Shea J. 7 Kanai Masahiro 2, Manuscript analyses team leader, Manuscript analyses team member: meta-analysis Mehtonen Juha 1, Manuscript analyses team member: heritability, methods and supplements, Manuscript analyses team member: PHEWAS, Manuscript analyses team member: Mendelian randomization, Manuscript analyses team member: PC projection and gene prioritization, Manuscript analyses team member: gene prioritization Finucane Hilary 3 29, Manuscript analyses team member: sensitivity analysis Cordioli Mattia 1, Manuscript analyses team members: PC projection Martin Alicia R. 3 29 Zhou Wei 3 29, In silico analysis team members Pasaniuc Bogdan 32 Julienne Hanna 33 Aschard Hugues 33 Shi Huwenbo 34 Yengo Loic 35 Polimanti Renato 6 Ghoussaini Maya 15 38 Schwartzentruber Jeremy 15 38 Dunham Ian 15 40, Project management leader, Project management support Chwialkowska Karolina 42 Francescatto Margherita 43 Trankiem Amy 2 Balaconis
Publication date
2021/7/8
Journal
Nature
Volume
600
Issue
7889
Pages
472-477
Publisher
Nature Publishing Group UK
Description
The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-19,, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19 …
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