Authors
Vincent Cottin, H Nunes, PYet Brillet, P Delaval, G Devouassoux, I Tillie-Leblond, D Israel-Biet, D Valeyre, Jean-François Cordier
Publication date
2005/10/1
Journal
European Respiratory Journal
Volume
26
Issue
4
Pages
586-593
Publisher
European Respiratory Society
Description
The syndrome resulting from combined pulmonary fibrosis and emphysema has not been comprehensively described.
The current authors conducted a retrospective study of 61 patients with both emphysema of the upper zones and diffuse parenchymal lung disease with fibrosis of the lower zones of the lungs on chest computed tomography.
Patients (all smokers) included 60 males and one female, with a mean age of 65 yrs. Dyspnoea on exertion was present in all patients. Basal crackles were found in 87% and finger clubbing in 43%. Pulmonary function tests were as follows (mean±sd): total lung capacity 88%±17, forced vital capacity (FVC) 88%±18, forced expiratory volume in one second (FEV1) 80%±21 (% predicted), FEV1/FVC 69%±13, carbon monoxide diffusion capacity of the lung 37%±16 (% predicted), carbon monoxide transfer coefficient 46%±19. Pulmonary hypertension was present in 47 …
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V Cottin, H Nunes, PY Brillet, P Delaval… - European Respiratory Journal, 2005