Authors
Michelle O'Shaughnessy, Niamh Allen, John O'Regan, Edwina Payne-Danson, Lise Mentre, Dawn Davin, Peter Lavin, Tamasine Grimes
Publication date
2017/10/1
Journal
QJM: An International Journal of Medicine
Volume
110
Issue
10
Pages
623-628
Publisher
Oxford University Press
Description
Background
Chronic kidney disease (CKD) is a risk factor for adverse drug events. The clinical significance of discordance between renal prescribing references is unknown.
Aim
We determined the prevalence of potentially inappropriate prescribing (PIP) in CKD, measured agreement between two prescribing references, and assessed potential for harm consequent to PIP.
Design
Single-centre observational study.
Methods
A random sample of hospitalized patients with CKD were grouped according to baseline CKD stage (3, 4, or 5). Prescriptions requiring caution in CKD were referenced against the Renal Drug Handbook (RDH) and British National Formulary (BNF) to identify PIP (non-compliance with recommendations). Inter-reference agreement was measured using percentage agreement and Kappa coefficient. Potential for harm …
Scholar articles
M O'Shaughnessy, N Allen, J O'Regan… - QJM: An International Journal of Medicine, 2017