Authors
Michele Cavallari, Miklos Palotai, Bonnie I Glanz, Svetlana Egorova, Juan Carlos Prieto, Brian C Healy, Tanuja Chitnis, Charles RG Guttmann
Publication date
2016/12
Journal
Multiple Sclerosis Journal
Volume
22
Issue
14
Pages
1841-1849
Publisher
SAGE Publications
Description
Background
It is unclear whether fatigue is a consequence or a predictive trait of disease worsening.
Objective
To investigate the predictive value of fatigue toward conversion to confirmed moderate–severe disability in patients with relapsing-remitting multiple sclerosis (RRMS).
Methods
We retrospectively selected from the Comprehensive Longitudinal Investigations in MS at the Brigham and Women’s Hospital (CLIMB) study cohort RRMS patients who converted to confirmed (⩾2 years) Expanded Disability Status Scale (EDSS) score ⩾3 within a follow-up period ⩾3 years. We contrasted the Modified Fatigue Impact Scale (MFIS) score of 33 converters, obtained at least 1 year before conversion to EDSS ⩾3, with that of 33 non-converter RRMS patients matched for baseline characteristics.
Results
Total MFIS score was higher in converter versus non-converter MS patients (median 37 vs 13; p < 0.0001). EDSS and …
Scholar articles
M Cavallari, M Palotai, BI Glanz, S Egorova, JC Prieto… - Multiple Sclerosis Journal, 2016