Authors
Sonja Stojanovski, Daniel Felsky, Joseph D Viviano, Saba Shahab, Rutwik Bangali, Christie L Burton, Gabriel A Devenyi, Lauren J O’Donnell, Peter Szatmari, M Mallar Chakravarty, Stephanie Ameis, Russell Schachar, Aristotle N Voineskos, Anne L Wheeler
Publication date
2019/3/1
Journal
Biological Psychiatry
Volume
85
Issue
5
Pages
408-416
Publisher
Elsevier
Description
Background
Attention-deficit/hyperactivity disorder (ADHD) is a major sequela of traumatic brain injury (TBI) in youths. The objective of this study was to examine whether ADHD symptoms are differentially associated with genetic risk and brain structure in youths with and without a history of TBI.
Methods
Medical history, ADHD symptoms, genetic data, and neuroimaging data were obtained from a community sample of youths. ADHD symptom severity was compared between those with and without TBI (TBI n = 418, no TBI n = 3193). The relationship of TBI history, genetic vulnerability, brain structure, and ADHD symptoms was examined by assessing 1) ADHD polygenic score (discovery sample ADHD n = 19,099, control sample n = 34,194), 2) basal ganglia volumes, and 3) fractional anisotropy in the corpus callosum and corona radiata.
Results
Youths with TBI reported greater ADHD symptom severity compared with …
Scholar articles
S Stojanovski, D Felsky, JD Viviano, S Shahab… - Biological Psychiatry, 2019