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A rapid increase of social media services in recent years has enabled people to share and seek information effectively. The openness, how-ever, also makes them one of the most effective channels for misinformation. Given the speed of information diffusion on social networks coupled with the widespread propagation of fake news [55], phishing URLs [24], and inaccurate information [37], misinformation escalates and can significantly impact users with undesirable consequences and wreak havoc instantaneously. In this chapter, we discuss the generation and diffusion of misinformation in social media, and introduce challenges of identification, intervention, and preventionmethods. We use examples to illustrate how to mine misinformation in social media, and also suggest possible future work.