Authors
Karl Kochanowski, Uwe Sauer, Victor Chubukov
Publication date
2013/12/1
Source
Current opinion in biotechnology
Volume
24
Issue
6
Pages
987-993
Publisher
Elsevier Current Trends
Description
Highlights
- Role of transcription in regulating metabolic fluxes is currently highly debated.
- Flux distributions are resilient against perturbations of transcriptional networks.
- Findings suggest that many enzymes in central metabolism are overabundant.
- Overabundance may protect from fluctuations and allow more rapid responses.
- New ‘omics’ studies further highlight the suboptimal regulation of gene expression.
The most common way for microbes to control their metabolism is by controlling enzyme levels through transcriptional regulation. Yet recent studies have shown that in many cases, perturbations to the transcriptional regulatory network do not result in altered metabolic phenotypes on the level of the flux distribution. We suggest that this may be a consequence of cells protecting their metabolism against stochastic fluctuations in expression as well as enabling a fast response for those fluxes that may need to be …
Scholar articles
K Kochanowski, U Sauer, V Chubukov - Current opinion in biotechnology, 2013