Authors
Daniela Sia, Yujin Hoshida, Augusto Villanueva, Sasan Roayaie, Joana Ferrer, Barbara Tabak, Judit Peix, Manel Sole, Victoria Tovar, Clara Alsinet, Helena Cornella, Brandy Klotzle, Jian–Bing Fan, Christian Cotsoglou, Swan N Thung, Josep Fuster, Samuel Waxman, Juan Carlos Garcia–Valdecasas, Jordi Bruix, Myron E Schwartz, Rameen Beroukhim, Vincenzo Mazzaferro, Josep M Llovet
Publication date
2013/4/1
Journal
Gastroenterology
Volume
144
Issue
4
Pages
829-840
Publisher
WB Saunders
Description
BACKGROUND & AIMS
Cholangiocarcinoma, the second most common liver cancer, can be classified as intrahepatic cholangiocarcinoma (ICC) or extrahepatic cholangiocarcinoma. We performed an integrative genomic analysis of ICC samples from a large series of patients.
METHODS
We performed a gene expression profile, high-density single-nucleotide polymorphism array, and mutation analyses using formalin-fixed ICC samples from 149 patients. Associations with clinicopathologic traits and patient outcomes were examined for 119 cases. Class discovery was based on a non-negative matrix factorization algorithm and significant copy number variations were identified by Genomic Identification of Significant Targets in Cancer (GISTIC) analysis. Gene set enrichment analysis was used to identify signaling pathways activated in specific molecular classes of tumors, and to analyze their genomic overlap with …
Scholar articles
D Sia, Y Hoshida, A Villanueva, S Roayaie, J Ferrer… - Gastroenterology, 2013