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In this study, we investigated the links between distance education students’ mental health, connectedness, and academic performance during COVID-19, using a mixed-methods sequential explanatory design. Online survey responses with a sample of 208 distance education students—aged 18–84, 144 females, 60 males, three nonbinary individuals, most (163) self-identified as White British—were analyzed using multiple regression, mediation, and content analysis. Connectedness (loneliness and a sense of connection to university) mediated links between mental health (wellbeing and anxiety) and academic performance. A subsample analysis with students who met clinical concern thresholds of anxiety and wellbeing (n = 123) revealed that poorer wellbeing was associated with less emotional intimacy, more loneliness, and poorer self-reported academic performance. Anxiety was associated with less …