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In wheat improvement programs development of new high yielding varieties requires information about, inheritance mechanism, identification of superior germplasm and combining ability of parents to transmit desirable attributes to offspring. In the current study, three genetically diverse elite advanced lines ie PR-105, PR-108 and PR-109 and three commercial wheat cultivars Faisalabad-2008, Lasani-2008 and Pirsabak-2013 were sown in crossing block during 2013-14. They were crossed in line× tester mating design to develop F 1 hybrids. F 1 hybrids along with their parents were evaluated in randomized complete block design with three replications at Cereal Crops Research Institute Pirsabak, Nowshera Khyber Pakhtunkhwa-Pakistan during 2014-15 for seven important traits. Analysis of variance revealed highly significant (P≤ 0.01) differences among the genotypes for the studied traits. Based on desirable General Combining Ability (GCA) effects, among the lines and testers, line (PR-105) and tester (Faisalabad-2008) were found best for earlier heading, maturity and high grain yield. Based on desirable Specific Combining Ability (SCA) effects, crosses, PR-109× Lasani-2008 (for days to heading and maturity), PR-108× Pirsabak-2013 (for flag leaf area),(PR-108× Faisalabad-2008 (for biological yield) and PR-105× Lasani-2008 (for grain yield) were best specific hybrids involving high× low and high× high GCA effects of parents and could be advanced to later segregating generation to extract potential transgressive segregants lines. Contribution of lines× tester interaction to the total variation was greater than lines and testers individually …