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GAVIN, TP, JP BABINGTON, CA HARMS, ME ARDELT, DA TANNER, and JM STAGER. Clothing fabric does not affect thermoregulation during exercise in moderate heat. Med. Sci. Sports Exerc., Vol. 33, No. 12, 2001, pp. 2124–2130. We investigated whether temperature regulation is improved during exercise in moderate heat by the use of clothing constructed from fabric that was purported to promote sweat evaporation compared with traditional fabrics. Eight well-trained, euhydrated males performed three exercise bouts wearing garments made from an evaporative polyester fabric (SYN), wearing garments made from traditional cotton fabric (COT), or dressed seminude (SN) in random order. Bouts consisted of 15 min seated rest, 30 min running at 70% VO2max, 15 min walking at 40% VO2max, and 15 min seated rest, all at 30 1 C and 35 5% relative humidity. COT and SYN clothing ensembles consisted of crew neck, short sleeve T-shirts, cycling shorts, and anklet socks made from their respective materials, and running shoes. The SN condition consisted of a Lycra swim suit, polyester socks, and running shoes. Mean skin temperature was lower for SN during preexercise rest when compared with SYN and COT. No differences in mean body temperature, rectal temperature, or mean skin temperature were observed during or after exercise. No differences in VO2 or heart rate were observed. No differences in comfort sensations were observed. In summary, before, during, or after exercise in a moderately warm environmental condition, neither the addition of a modest amount of clothing nor the fabric …