Authors
Melissa A Reed, Walter J Pories, William Chapman, John Pender, Rita Bowden, Hisham Barakat, Timothy P Gavin, Tom Green, Ed Tapscott, Donghai Zheng, Nigel Shankley, Lynn Yieh, David Polidori, Steven P Piccoli, Leona Brenner-Gati, G Lynis Dohm
Publication date
2011/8/1
Journal
The Journal of Clinical Endocrinology & Metabolism
Volume
96
Issue
8
Pages
2525-2531
Publisher
Oxford University Press
Description
Context
Roux-en-Y gastric bypass (RYGB) has been shown to induce rapid and durable reversal of type 2 diabetes.
Objective
The aim of the study was to investigate a possible mechanism for the remission of type 2 diabetes after RYGB.
Design
A cross-sectional, nonrandomized, controlled study was conducted. Surgery patients were studied before RYGB and 1 wk and 3 months after surgery.
Setting
This study was conducted at East Carolina University.
Subjects
Subjects were recruited into three groups: 1) lean controls with no surgery [body mass index (BMI) < 25 kg/m2; n = 9], 2) severely obese type 2 diabetic patients (BMI > 35 kg/m2; n = 9), and 3) severely obese nondiabetic patients (BMI > 35 kg/m2; n = 9).
Intervention
Intervention was RYGB.
Results
One week after …
Total citations
Scholar articles
Roux-en-Y gastric bypass corrects hyperinsulinemia implications for the remission of type 2 diabetes
MA Reed, WJ Pories, W Chapman, J Pender… - The Journal of Clinical Endocrinology & Metabolism, 2011