Authors
Timothy P Gavin, Rebecca S Ruster, John A Carrithers, Kevin A Zwetsloot, Raymond M Kraus, Christopher A Evans, Deborah J Knapp, James L Drew, Jennifer S McCartney, Joseph P Garry, Robert C Hickner
Publication date
2007/11/15
Journal
The Journal of physiology
Volume
585
Issue
1
Pages
231-239
Publisher
Blackwell Publishing Ltd
Description
Ischaemia‐induced skeletal muscle angiogenesis is impaired in aged compared with young mice. In humans, vascular endothelial growth factor (VEGF) mRNA and protein following an acute exercise bout are lower in aged compared with young untrained men. We hypothesized that exercise‐induced skeletal muscle angiogenesis would be attenuated in aged compared with young men. In eight aged (mean age: 64 years) and six young (mean age: 25 years) sedentary men, muscle biopsies were obtained from the vastus lateralis prior to (Pre), after 1 week and after 8 weeks of an aerobic exercise training program for the measurement of capillarization and VEGF mRNA. Dialysate VEGF protein collected from the muscle interstitial space was measured at rest and during submaximal exercise at Pre, 1 week and 8 weeks. Exercise training increased capillary contacts (CC) and capillary‐to‐fibre perimeter exchange …
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Scholar articles
TP Gavin, RS Ruster, JA Carrithers, KA Zwetsloot… - The Journal of physiology, 2007