Authors
TP Gavin, JL Drew, CJ Kubik, WE Pofahl, RC Hickner
Publication date
2007/10
Journal
Acta physiologica
Volume
191
Issue
2
Pages
139-146
Publisher
Blackwell Publishing Ltd
Description
Aims:  Both aerobic and resistance exercise training promote skeletal muscle angiogenesis. Acute aerobic exercise increases several pro‐angiogenic pathways, the best characterized being increases in vascular endothelial growth factor (VEGF). We hypothesized that acute resistance exercise also increases skeletal muscle angiogenic growth factor [VEGF and angiopoietin (Ang)] expression.
Methods:  Seven young, sedentary individuals had vastus lateralis muscle biopsies and blood drawn prior to and at 0, 2 and 4 h post‐resistance exercise for the measurement of VEGF; VEGF receptor [KDR, Flt‐1 and neuropilin 1 (Nrp1)]; Ang1 and Ang2; and the angiopoietin receptor – Tie2 expression. Resistance exercise consisted of progressive knee extensor (KE) exercise to determine one repetition maximum (1‐RM) followed by three sets of 10 repetitions (3 × 10) of KE exercise at 60–80% of 1‐RM.
Results …
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