Authors
Gyungah Jun, Carla A Ibrahim-Verbaas, Maria Vronskaya, Jean-Charles Lambert, Jaeyoon Chung, Adam C Naj, Brian W Kunkle, Li-San Wang, Joshua C Bis, Céline Bellenguez, Denise Harold, Kathryn L Lunetta, Anita L Destefano, Benjamin Grenier-Boley, Rebecca Sims, Gary W Beecham, Albert V Smith, Vincent Chouraki, Kara L Hamilton-Nelson, M Arfan Ikram, Nathalie Fievet, Nicola Denning, Eden R Martin, Helena Schmidt, Yochiro Kamatani, Melanie L Dunstan, Otto Valladares, Agustin Ruiz Laza, Diana Zelenika, Alfredo Ramirez, Tatiana M Foroud, Seung-Hoan Choi, Anne Boland, Tim Becker, Walter A Kukull, Sven J Van Der Lee, Florence Pasquier, Carlos Cruchaga, Duane Beekly, Annette L Fitzpatrick, Oliver Hanon, Michael Gill, Robert Barber, Vilmundur Gudnason, Dominique Campion, Seth Love, David A Bennett, Najaf Amin, Claudine Berr, Magda Tsolaki, Joseph D Buxbaum, Oscar L Lopez, Vincent Deramecourt, Nick C Fox, Laura B Cantwell, Lluis Tárraga, Carole Dufouil, John Hardy, Paul K Crane, Gudny Eiriksdottir, Didier Hannequin, Robert Clarke, Denis Evans, Thomas H Mosley, Luc Letenneur, Carol Brayne, Wolfgang Maier, Philip De Jager, Valur Emilsson, Jean-François Dartigues, Harald Hampel, M Ilyas Kamboh, Renee FAG De Bruijn, Christophe Tzourio, Pau Pastor, Eric B Larson, Jerome I Rotter, Michael C O'Donovan, Thomas J Montine, Michael A Nalls, Simon Mead, Eric M Reiman, Palmi V Jonsson, Clive Holmes, St George-Hyslop, Mercè Boada, Peter Passmore, Jens R Wendland, Reinhold Schmidt, Kevin Morgan, Ashley R Winslow, John F Powell, Minerva Carasquillo, Steven G Younkin, Jóhanna Jakobsdóttir, John SK Kauwe, Kirk C Wilhelmsen, Dan Rujescu, Markus M Nöthen, Albert Hofman, Lesley Jones, Jonathan L Haines, Bruce M Psaty, Christine Van Broeckhoven, Peter Holmans, Lenore J Launer, Richard Mayeux, Mark Lathrop, Alison M Goate, Valentina Escott-Price, Sudha Seshadri, Margaret A Pericak-Vance, Philippe Amouyel, Julie Williams, Cornelia M Van Duijn, Gerard D Schellenberg, Lindsay A Farrer
Publication date
2016/1
Journal
Molecular psychiatry
Volume
21
Issue
1
Pages
108-117
Publisher
Nature Publishing Group
Description
APOE ɛ4, the most significant genetic risk factor for Alzheimer disease (AD), may mask effects of other loci. We re-analyzed genome-wide association study (GWAS) data from the International Genomics of Alzheimer’s Project (IGAP) Consortium in APOE ɛ4+(10 352 cases and 9207 controls) and APOE ɛ4−(7184 cases and 26 968 controls) subgroups as well as in the total sample testing for interaction between a single-nucleotide polymorphism (SNP) and APOE ɛ4 status. Suggestive associations (P< 1× 10-4) in stage 1 were evaluated in an independent sample (stage 2) containing 4203 subjects (APOE ɛ4+: 1250 cases and 536 controls; APOE ɛ4−: 718 cases and 1699 controls). Among APOE ɛ4− subjects, novel genome-wide significant (GWS) association was observed with 17 SNPs (all between KANSL1 and LRRC37A on chromosome 17 near MAPT) in a meta-analysis of the stage 1 and stage 2 data sets …
Scholar articles
G Jun, CA Ibrahim-Verbaas, M Vronskaya, JC Lambert… - Molecular psychiatry, 2016